ETAZOLATE
- Product Name
- ETAZOLATE
- CAS No.
- 35838-58-5
- Chemical Name
- ETAZOLATE
- Synonyms
- Nsc163611;Etazolate hydrochloride solid;Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo[3,4-B]pyridine-5-carboxylate monohydrochloride;1-ethyl-4-[(1-methylethylidene)hydrazino]1h-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;1H-Pyrazolo[3,4-B]pyridine-5-carboxylic acid, 1-ethyl-4-[(1-methylethylidene)hydrazino]-, ethyl ester, monohydrochloride;SQ20009, 1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride
- CBNumber
- CB4972600
- Molecular Formula
- C14H18N5O2HCl
- Formula Weight
- 0
- MOL File
- 35838-58-5.mol
ETAZOLATE Property
- Melting point:
- 193-194 °C
- storage temp.
- room temp
- solubility
- H2O: >20mg/mL (Solutions should be freshly prepared.)
- form
- solid
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E889255
- Product name
- Etazolate hydrochloride
- Packaging
- 10mg
- Price
- $575
- Updated
- 2021/12/16
- Product number
- B6304
- Product name
- Etazolate hydrochloride
- Packaging
- 10mM(in 1mL H2O)
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B6304
- Product name
- Etazolate hydrochloride
- Packaging
- 10mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- B6304
- Product name
- Etazolate hydrochloride
- Packaging
- 50mg
- Price
- $419
- Updated
- 2021/12/16
- Product number
- API0008346
- Product name
- ETAZOLATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $1024.78
- Updated
- 2021/12/16
ETAZOLATE Chemical Properties,Usage,Production
Uses
Antipsychotic.
Uses
Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.
Biological Activity
etazolate hydrochloride is a pde-4 inhibitor and selective gaba-a receptor modulator [3].pde-4 modulates the release of inflammatory mediators through camp-dependent and -independent mechanisms. selective targeting pde-4 is a novel therapeutic approach in the treatment of inflammation-associated respiratory diseases, such as asthma and copd (chronic obstructive pulmonary disease) [1].in rat neuronal cortical cells, etazolate hydrochloride (0.2 μm) induced sappα through the stimulation of the α-secretase pathway, and exerted a neuroprotective effect against aβ which was associated with sappα induction via the gaba-a receptor [2].in 159 alzheimer’s disease patients, etazolate hydrochloride in combination with one achei (acetycholinesterase inhibitor) was shown to be safe and generally well tolerated in the phase iia study over a 3-month treatment period [3].
Biochem/physiol Actions
Selective inhibitor of cAMP-specific phosphodiesterase.
References
[1] dastidar s g, rajagopal d, ray a. therapeutic benefit of pde4 inhibitors in inflammatory diseases.[j]. current opinion in investigational drugs, 2007, 8(5):364-72.
[2] marcade m, bourdin j, loiseau n, et al. etazolate, a neuroprotective drug linking gaba(a) receptor pharmacology to amyloid precursor protein processing.[j]. journal of neurochemistry, 2008, 106(1):392-404.
[3] vellas b; sol o; snyder pj; ousset pj; haddad r; maurin m; lemarié jc; désiré l; pando mp; eht0202/002 study group. eht0202 in alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study.[j]. current alzheimer research, 2011, 8(2):203-12.